Since its first approval by the FDA in 2017, tremendous progress has been made in chimeric antigen receptor (CAR) T cell therapy, the adoptive transfer of engineered, CAR-expressing T lymphocyte.CAR T cells are all composed of three main elements: an extracellular antigen-binding domain, an intracellular signaling domain responsible for T cell acti
Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer.This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating to function of the protein as a promoter of metastasis.Different mechanisms are summarized illustrating how CAV1 promotes such t
Cadmium (Cd) and arsenic (As) are widely distributed pollutants that co-exist in the environment; however, their joint toxicity on living organisms is still largely unknown.In this study, we explored the joint toxicity of concurrent exposure to Cd and different As species at low concentrations on Caenorhabditis elegans (C.elegans) in comparison to
In this review, we give an overview of recent cultivation systems in commercial plum orchards.The aspects of selecting the shape flavored-lube of the crown and the spacing of trees are discussed first and then growth characteristics and the structure of the crow are described in detail.Finally, the wound healing Toe Protector and regeneration chara
Abstract Introduction: To prevent accidents and minimize the risk of unexpected disasters in the oil, gas, and petrochemical industries, an inspection of equipment in terms of mechanical integrity and safe and consistent service providing are of utmost importance.The purpose of this study is integrated risk and asset management by implementing risk